Unraveling the mysteries of protein folding and misfolding
نویسندگان
چکیده
منابع مشابه
Unraveling the mysteries of protein folding and misfolding.
This mini-review focuses on the processes and consequences of protein folding and misfolding. The latter process often leads to protein aggregation and precipitation with the aggregates adopting either highly ordered (amyloid fibril) or disordered (amorphous) forms. In particular, the amyloid fibril is discussed because this form has gained considerable notoriety due to its close links to a var...
متن کاملExperimental investigation of protein folding and misfolding.
Newly synthesised proteins need to fold, often to intricate and close-packed structures, in order to function. The underlying mechanism by which this complex process takes place both in vitro and in vivo is now becoming understood, at least in general terms, as a result of the application of a wide range of biophysical and computational methods used in combination with the techniques of biochem...
متن کاملPrinciples of protein folding, misfolding and aggregation.
This review summarises our current understanding of the underlying and universal mechanism by which newly synthesised proteins achieve their biologically functional states. Protein molecules, however, all have a finite tendency either to misfold, or to fail to maintain their correctly folded states, under some circumstances. This article describes some of the consequences of such behaviour, par...
متن کاملUnraveling protein misfolding diseases using model systems
Experimental model systems have long been used to probe the causes, consequences and mechanisms of pathology leading to human disease. Ideally, such information can be exploited to inform the development of therapeutic strategies or treatments to combat disease progression. In the case of protein misfolding diseases, a wide range of model systems have been developed to investigate different asp...
متن کاملProtein folding and misfolding: mechanism and principles.
Two fundamentally different views of how proteins fold are now being debated. Do proteins fold through multiple unpredictable routes directed only by the energetically downhill nature of the folding landscape or do they fold through specific intermediates in a defined pathway that systematically puts predetermined pieces of the target native protein into place? It has now become possible to det...
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ژورنال
عنوان ژورنال: IUBMB Life
سال: 2008
ISSN: 1521-6543,1521-6551
DOI: 10.1002/iub.117